5-Aminolevulinic acid (5-ALA) and porphobilinogen (PBG) are intermediates in the biosynthesis of heme and hemoglobin. In certain diseases, called porphyrias, an accumulation of 5-ALA and PBG is observed due to abnormalities in the heme production. Besides to a genetic disposition (hereditary porphyrias), porphyrias may also be induced by several external factors, mostly by lead intoxication.

Here, the RECIPE column test (no HPLC method) serves as a quick test for the assessment of porphyrias and lead intoxications. The results can be verified by an additional determination of the total porphyrins (column test with order no. 17100). In case of a porphyria, a differentiated diagnosis can be established by use of the urinary porphyrin excreetion profile (HPLC determination of the differentiated porphyrins, order no. 17000).

• Cost-efficient quick test
  (column test)
  
  

• Easy handling
  
  
  
• Urine calibrator and controls available
  
  
  
• Additional tests for the determination of total and differentiated porphyrins available

Test Data

Sample Preparation